Computer gaming is now a regular part of life for many people. Beyond just being entertaining, though, it can be a very useful tool in education and in science. If people spent just a fraction of their play time solving real-life scientific puzzles—by playing science-based computer games—what new knowledge might we uncover? Professor James Bardwell and Scott Horowitz, a research fellow, examine how a popular game like Foldit is helping to advance the science of biochemistry through “gamesourcing.”