{"id":27085,"date":"2023-06-26T15:33:51","date_gmt":"2023-06-26T19:33:51","guid":{"rendered":"https:\/\/michigan.it.umich.edu\/news\/?p=27085"},"modified":"2024-07-08T06:04:16","modified_gmt":"2024-07-08T10:04:16","slug":"u-ms-ai-for-nanobiotics-stopping-antibiotic-resistant-infections","status":"publish","type":"post","link":"https:\/\/michigan.it.umich.edu\/news\/2023\/06\/26\/u-ms-ai-for-nanobiotics-stopping-antibiotic-resistant-infections\/","title":{"rendered":"U-M\u2019s AI for Nanobiotics: Stopping antibiotic-resistant infections"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">In 2019, 4.95 million people died from antimicrobial resistance. \u201cEven before COVID, which worsened the problem, studies showed that by 2050, the number of deaths by antibiotic resistance will be 10 million,\u201d said <a href=\"https:\/\/me.engin.umich.edu\/people\/faculty\/angela-violi\/\">Angela Violi<\/a>, a professor of six studies and U-M Arthur F. Thurnau Professor of mechanical engineering.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A new computer model has been developed at the University of Michigan to help find ways to stop antibiotic-resistant infections and new viruses, and assist in the design of nanoparticles for a variety of treatment purposes.<\/p>\n\n\n\n<iframe loading=\"lazy\" width=\"672\" height=\"378\" src=\"https:\/\/www.youtube.com\/embed\/52H-8xReZM4\" title=\"Using Nanoparticles to Combat Antibiotic Resistance Bacteria\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" allowfullscreen><\/iframe>\n\n\n\n<p class=\"has-cyan-bluish-gray-color has-text-color has-small-font-size wp-block-paragraph\">More information is also available in the article, <a href=\"https:\/\/news.engin.umich.edu\/2023\/06\/nanobiotics-ai-for-discovering-where-and-how-nanoparticles-bind-with-proteins\/\">Nanobiotics: AI for discovering where and how nanoparticles bind with proteins<\/a>, by Kate McAlpine.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The computer model, NeCLAS, uses AI machine learning techniques to absorb the structural models of proteins and their interaction sites. Once it has this information, it learns how these proteins and nanoparticles might interact, and is able to learn and predict binding sites and their likelihoods, as well as predicting the interactions between two select proteins or nanoparticles.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This is an important step in being able to design antibiotics and antivirals on demand.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Other models exist but NeCLAS, \u201cgoes beyond,\u201d said U-M chemical engineering doctoral student Jacob Saldinger, \u201cby showing how nanostructures will interact with one another, and it\u2019s not limited to proteins. This enables researchers to understand the potential applications of nanoparticles and optimize their designs.\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cBesides being more general, NeCLAS also uses way less training data,\u201d said electrical and computer engineering doctoral student Matt Raymond. \u201cWe only have 21 nanoparticles to look at, so we have to use protein data in a clever way.\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The team tested three case studies for which they had additional data: using binds as molecular tweezers, how graphene quantum dots break up the biofilm produced by staph bacteria, and whether graphene quantum dots would disperse in water.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"467\" src=\"https:\/\/michigan.it.umich.edu\/news\/wp-content\/uploads\/2023\/06\/molecular-tweezers-600x467.jpeg\" alt=\"A nanoparticle. A set of yellow balls attached by netting fits neatly around a very specific protrusion on a protein, marked in blue.\" class=\"wp-image-27087\" srcset=\"https:\/\/michigan.it.umich.edu\/news\/wp-content\/uploads\/2023\/06\/molecular-tweezers-600x467.jpeg 600w, https:\/\/michigan.it.umich.edu\/news\/wp-content\/uploads\/2023\/06\/molecular-tweezers-300x234.jpeg 300w, https:\/\/michigan.it.umich.edu\/news\/wp-content\/uploads\/2023\/06\/molecular-tweezers-768x598.jpeg 768w, https:\/\/michigan.it.umich.edu\/news\/wp-content\/uploads\/2023\/06\/molecular-tweezers-1536x1196.jpeg 1536w, https:\/\/michigan.it.umich.edu\/news\/wp-content\/uploads\/2023\/06\/molecular-tweezers-665x518.jpeg 665w, https:\/\/michigan.it.umich.edu\/news\/wp-content\/uploads\/2023\/06\/molecular-tweezers.jpeg 1741w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><figcaption class=\"wp-element-caption\">The new computer model, NeCLAS, predicts that a nanoparticle, shown as a set of yellow balls attached by netting, fits neatly around a very specific protrusion on a protein, marked in blue. The binding site is confirmed by experiments. These kinds of nanoparticles, called molecular tweezers, can be used to throw a wrench into the workings of pathogens and toxic protein aggregations. Credit: Paolo Elvati, Violi Lab, University of Michigan.<\/figcaption><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cWithout experimental data, you don\u2019t have a starting point for how these proteins and nanoparticles will interact,\u201d said Chloe Luyet, a U-M doctoral student in the Violi group. \u201cNeCLAS can tell me which parts should be closer together at the beginning of the simulation.\u201d&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Next, the team intends to explore other biofilms and microorganisms, including viruses.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Article summarized from Michigan Engineering: <a href=\"https:\/\/news.engin.umich.edu\/2023\/06\/nanobiotics-ai-for-discovering-where-and-how-nanoparticles-bind-with-proteins\/\">Nanobiotics: AI for discovering where and how nanoparticles bind with proteins<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In 2019, 4.95 million people died from antimicrobial resistance. \u201cEven before COVID, which worsened the problem, studies showed that by 2050, the number of deaths by antibiotic resistance will be 10 million,\u201d said Angela Violi, a professor of six studies and U-M Arthur F. Thurnau Professor of mechanical engineering. A new computer model has been developed at the\u2026 <span class=\"read-more\"><a href=\"https:\/\/michigan.it.umich.edu\/news\/2023\/06\/26\/u-ms-ai-for-nanobiotics-stopping-antibiotic-resistant-infections\/\">Read More &raquo;<\/a><\/span><\/p>\n","protected":false},"author":191,"featured_media":27087,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_uag_custom_page_level_css":"","_umich_oidc_access":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_ef_editorial_meta_date_first-draft-date":"","_ef_editorial_meta_paragraph_assignment":"","_ef_editorial_meta_checkbox_needs-photo":"","_ef_editorial_meta_number_word-count":"","footnotes":""},"categories":[5],"tags":[61,1012,130,563],"class_list":["post-27085","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-campus-news","tag-ai","tag-nanobiotics","tag-research","tag-virus"],"uagb_featured_image_src":{"full":["https:\/\/michigan.it.umich.edu\/news\/wp-content\/uploads\/2023\/06\/molecular-tweezers.jpeg",1741,1356,false],"thumbnail":["https:\/\/michigan.it.umich.edu\/news\/wp-content\/uploads\/2023\/06\/molecular-tweezers-400x266.jpeg",400,266,true],"medium":["https:\/\/michigan.it.umich.edu\/news\/wp-content\/uploads\/2023\/06\/molecular-tweezers-300x234.jpeg",300,234,true],"medium_large":["https:\/\/michigan.it.umich.edu\/news\/wp-content\/uploads\/2023\/06\/molecular-tweezers-768x598.jpeg",665,518,true],"large":["https:\/\/michigan.it.umich.edu\/news\/wp-content\/uploads\/2023\/06\/molecular-tweezers-600x467.jpeg",600,467,true],"1536x1536":["https:\/\/michigan.it.umich.edu\/news\/wp-content\/uploads\/2023\/06\/molecular-tweezers-1536x1196.jpeg",1536,1196,true],"2048x2048":["https:\/\/michigan.it.umich.edu\/news\/wp-content\/uploads\/2023\/06\/molecular-tweezers.jpeg",1741,1356,false],"excerpt-thumbnail":["https:\/\/michigan.it.umich.edu\/news\/wp-content\/uploads\/2023\/06\/molecular-tweezers-200x140.jpeg",200,140,true],"themonic-thumbnail":["https:\/\/michigan.it.umich.edu\/news\/wp-content\/uploads\/2023\/06\/molecular-tweezers-60x42.jpeg",60,42,true],"ioslider-thumbnail":["https:\/\/michigan.it.umich.edu\/news\/wp-content\/uploads\/2023\/06\/molecular-tweezers-658x300.jpeg",658,300,true],"post-thumbnail":["https:\/\/michigan.it.umich.edu\/news\/wp-content\/uploads\/2023\/06\/molecular-tweezers-665x518.jpeg",665,518,true],"400x250-crop":["https:\/\/michigan.it.umich.edu\/news\/wp-content\/uploads\/2023\/06\/molecular-tweezers-400x250.jpeg",400,250,true]},"uagb_author_info":{"display_name":"Josephine Anderson","author_link":"https:\/\/michigan.it.umich.edu\/news\/author\/jganders\/"},"uagb_comment_info":0,"uagb_excerpt":"In 2019, 4.95 million people died from antimicrobial resistance. \u201cEven before COVID, which worsened the problem, studies showed that by 2050, the number of deaths by antibiotic resistance will be 10 million,\u201d said Angela Violi, a professor of six studies and U-M Arthur F. Thurnau Professor of mechanical engineering. A new computer model has been&hellip;","_links":{"self":[{"href":"https:\/\/michigan.it.umich.edu\/news\/wp-json\/wp\/v2\/posts\/27085","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/michigan.it.umich.edu\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/michigan.it.umich.edu\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/michigan.it.umich.edu\/news\/wp-json\/wp\/v2\/users\/191"}],"replies":[{"embeddable":true,"href":"https:\/\/michigan.it.umich.edu\/news\/wp-json\/wp\/v2\/comments?post=27085"}],"version-history":[{"count":3,"href":"https:\/\/michigan.it.umich.edu\/news\/wp-json\/wp\/v2\/posts\/27085\/revisions"}],"predecessor-version":[{"id":27089,"href":"https:\/\/michigan.it.umich.edu\/news\/wp-json\/wp\/v2\/posts\/27085\/revisions\/27089"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/michigan.it.umich.edu\/news\/wp-json\/wp\/v2\/media\/27087"}],"wp:attachment":[{"href":"https:\/\/michigan.it.umich.edu\/news\/wp-json\/wp\/v2\/media?parent=27085"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/michigan.it.umich.edu\/news\/wp-json\/wp\/v2\/categories?post=27085"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/michigan.it.umich.edu\/news\/wp-json\/wp\/v2\/tags?post=27085"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}