{"id":20539,"date":"2020-09-14T12:16:00","date_gmt":"2020-09-14T16:16:00","guid":{"rendered":"https:\/\/michigan.it.umich.edu\/news\/?p=20539"},"modified":"2024-07-08T06:04:48","modified_gmt":"2024-07-08T10:04:48","slug":"3d-modeling-could-help-develop-treatments-for-lung-disease-caused-by-covid-19","status":"publish","type":"post","link":"https:\/\/michigan.it.umich.edu\/news\/2020\/09\/14\/3d-modeling-could-help-develop-treatments-for-lung-disease-caused-by-covid-19\/","title":{"rendered":"3D modeling could help develop treatments for lung disease caused by COVID-19"},"content":{"rendered":"\n
\"2D
In line with prior work, myofibroblasts fail to accumulate in soft 2D settings (left). In the new 3d model (right) the myofibroblasts (magenta) accumulate, even in soft conditions that mimic a healthy lung. Images are stained for cytoskeleton (blue), cell nuclei (yellow), and a marker for myofibroblast activation (alpha-smooth muscle actin, magenta). (Baker Lab)<\/figcaption><\/figure><\/div>\n\n\n\n

A 3D bioengineered model of lung tissue<\/a> built by U-M researchers is poking holes in decades worth of flat, Petri dish observations into how the deadly disease pulmonary fibrosis progresses.\u00a0Some clinicians are concerned that critically ill COVID-19 patients may develop a form of pulmonary fibrosis after a long stay in the ICU.\u00a0<\/p>\n\n\n\n

Researchers are searching for better treatments. While they\u2019ve managed to find some drugs that relieve symptoms or slow the progression in practice, they can\u2019t always replicate those results in today\u2019s 2D lab models. So they don\u2019t understand how or why those drugs are working, and they can\u2019t always predict which compounds will make a difference. The new research from U-M takes a step in that direction, and it starkly demonstrates how prior approaches have been ineffective.<\/p>\n","protected":false},"excerpt":{"rendered":"

A 3D bioengineered model of lung tissue built by U-M researchers is poking holes in decades worth of flat, Petri dish observations into how the deadly disease pulmonary fibrosis progresses.\u00a0Some clinicians are concerned that critically ill COVID-19 patients may develop a form of pulmonary fibrosis after a long stay in the ICU.\u00a0 Researchers are searching for better treatments.\u2026 Read More »<\/a><\/span><\/p>\n","protected":false},"author":1,"featured_media":20540,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_uag_custom_page_level_css":"","_umich_oidc_access":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_ef_editorial_meta_date_first-draft-date":"","_ef_editorial_meta_paragraph_assignment":"","_ef_editorial_meta_checkbox_needs-photo":"","_ef_editorial_meta_number_word-count":"","footnotes":""},"categories":[5],"tags":[810,852,130],"class_list":["post-20539","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-campus-news","tag-covid","tag-engineering","tag-research"],"uagb_featured_image_src":{"full":["https:\/\/michigan.it.umich.edu\/news\/wp-content\/uploads\/2020\/09\/pf-5_2d-vs-3d.jpg",1560,780,false],"thumbnail":["https:\/\/michigan.it.umich.edu\/news\/wp-content\/uploads\/2020\/09\/pf-5_2d-vs-3d-200x100.jpg",200,100,true],"medium":["https:\/\/michigan.it.umich.edu\/news\/wp-content\/uploads\/2020\/09\/pf-5_2d-vs-3d-300x150.jpg",300,150,true],"medium_large":["https:\/\/michigan.it.umich.edu\/news\/wp-content\/uploads\/2020\/09\/pf-5_2d-vs-3d-768x384.jpg",665,333,true],"large":["https:\/\/michigan.it.umich.edu\/news\/wp-content\/uploads\/2020\/09\/pf-5_2d-vs-3d-700x350.jpg",600,300,true],"1536x1536":["https:\/\/michigan.it.umich.edu\/news\/wp-content\/uploads\/2020\/09\/pf-5_2d-vs-3d-1536x768.jpg",1536,768,true],"2048x2048":["https:\/\/michigan.it.umich.edu\/news\/wp-content\/uploads\/2020\/09\/pf-5_2d-vs-3d.jpg",1560,780,false],"excerpt-thumbnail":["https:\/\/michigan.it.umich.edu\/news\/wp-content\/uploads\/2020\/09\/pf-5_2d-vs-3d-200x140.jpg",200,140,true],"themonic-thumbnail":["https:\/\/michigan.it.umich.edu\/news\/wp-content\/uploads\/2020\/09\/pf-5_2d-vs-3d-60x42.jpg",60,42,true],"ioslider-thumbnail":["https:\/\/michigan.it.umich.edu\/news\/wp-content\/uploads\/2020\/09\/pf-5_2d-vs-3d-658x300.jpg",658,300,true],"post-thumbnail":["https:\/\/michigan.it.umich.edu\/news\/wp-content\/uploads\/2020\/09\/pf-5_2d-vs-3d-665x333.jpg",665,333,true],"400x250-crop":["https:\/\/michigan.it.umich.edu\/news\/wp-content\/uploads\/2020\/09\/pf-5_2d-vs-3d.jpg",400,200,false]},"uagb_author_info":{"display_name":"News Staff","author_link":"https:\/\/michigan.it.umich.edu\/news\/author\/mitnewsadm\/"},"uagb_comment_info":0,"uagb_excerpt":"A 3D bioengineered model of lung tissue built by U-M researchers is poking holes in decades worth of flat, Petri dish observations into how the deadly disease pulmonary fibrosis progresses.\u00a0Some clinicians are concerned that critically ill COVID-19 patients may develop a form of pulmonary fibrosis after a long stay in the ICU.\u00a0 Researchers are searching…","_links":{"self":[{"href":"https:\/\/michigan.it.umich.edu\/news\/wp-json\/wp\/v2\/posts\/20539","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/michigan.it.umich.edu\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/michigan.it.umich.edu\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/michigan.it.umich.edu\/news\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/michigan.it.umich.edu\/news\/wp-json\/wp\/v2\/comments?post=20539"}],"version-history":[{"count":2,"href":"https:\/\/michigan.it.umich.edu\/news\/wp-json\/wp\/v2\/posts\/20539\/revisions"}],"predecessor-version":[{"id":20612,"href":"https:\/\/michigan.it.umich.edu\/news\/wp-json\/wp\/v2\/posts\/20539\/revisions\/20612"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/michigan.it.umich.edu\/news\/wp-json\/wp\/v2\/media\/20540"}],"wp:attachment":[{"href":"https:\/\/michigan.it.umich.edu\/news\/wp-json\/wp\/v2\/media?parent=20539"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/michigan.it.umich.edu\/news\/wp-json\/wp\/v2\/categories?post=20539"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/michigan.it.umich.edu\/news\/wp-json\/wp\/v2\/tags?post=20539"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}